Artificial sweeteners, often marketed as a healthier alternative to sugar, are widely believed to aid in weight loss or management. However, a 2010 paper by Yang in The Yale Journal of Biology and Medicine challenges this assumption, suggesting that artificial sweeteners might not be the weight-loss solution they are often claimed to be. This summary highlights the key findings from Yang’s paper.

Epidemiological Evidence

Large cohort studies reveal a surprising trend: a positive correlation between artificial sweetener use and weight gain. These findings are counterintuitive, as many people consume these sweeteners to avoid the calories associated with sugar.

Longitudinal Studies

Several studies, such as the San Antonio Heart Study and the American Cancer Society study, have observed that regular users of artificial sweeteners tend to have a higher BMI over time compared to non-users. For instance, in the San Antonio Heart Study, participants who consumed artificially sweetened beverages had a more significant BMI increase over a seven-to-eight-year period than those who didn’t.

Children and Adolescents

This trend extends to younger populations. Increased consumption of diet sodas in children and adolescents is associated with higher BMI. The Growing Up Today Study reported that each daily serving of diet soda was linked to a notable BMI increase in boys.

Interventional Studies

Experimental trials replacing sugar-sweetened beverages with artificially sweetened ones do not consistently lead to weight loss. For example, a randomized controlled trial involving adolescents did not show a significant BMI reduction after substituting diet beverages for regular ones over 25 weeks.

Appetite and Energy Balance

One explanation for these findings is that artificial sweeteners might enhance appetite and increase food intake. The sweet taste without the caloric content can lead to a mismatch in the body’s energy balance, prompting individuals to eat more to satisfy their craving for sweetness.

Neurological Factors

Artificial sweeteners may fail to fully activate the brain’s reward pathways compared to natural sweeteners. This incomplete activation might lead to increased appetite and sugar cravings, driving people to consume more food in an attempt to achieve the desired satisfaction.

Behavioral Implications

The regular use of artificial sweeteners may contribute to sugar cravings and dependence. Over time, this can influence dietary preferences, potentially leading to higher overall calorie intake and weight gain.


While artificial sweeteners are a popular choice for those looking to reduce sugar intake and manage weight, Yang’s 2010 research indicates that they might not be as effective in promoting weight loss as commonly believed. In some cases, they may even contribute to weight gain by enhancing appetite and fostering sugar cravings. Therefore, a more holistic approach, such as reducing overall sweetness in the diet, might be necessary to combat obesity effectively.


  • Courtney Simons

    Dr. Courtney Simons has served as a food science researcher and educator for over a decade. He holds a Bachelor of Science in Food Science and a Ph.D. in Cereal Science from North Dakota State University.